Uncovering The Mechanisms That Support The Spread Of Ovarian Cancer

Uncovering The Mechanisms That Support The Spread Of Ovarian CancerA very high mortality rate is associated with ovarian cancer, in part due to difficulties in detecting and diagnosing the disease at early stages before tumors have spread, or metastasized, to other locations in the body.

During metastasis, ovarian tumor cells break away from the original tumor site into the abdominal cavity, where immune cells called macrophages help them survive and migrate to other locations.

In this issue of the JCI, research led by Wang Min at Yale University describes how a subtype of macrophages communicate with and support tumor cell growth to drive metastasis in ovarian cancer. Researchers determined that tumor cells attract macrophages by releasing cytokines.

These macrophages then secrete growth factors that help the tumor cells multiply to form tumor cell spheroids. In a mouse model of ovarian cancer, inhibiting these growth factors reduced the formation of tumor cell spheroids and ovarian tumor growth.

These findings add to an understanding of the early stages of ovarian tumor metastasis, which may lead to the development of more effective early diagnostic approaches as well as therapies to prevent metastasis.

To read this entire article on Medical Xpress, please click here.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s